Article
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.
Nature cell biology - 1 Jul 2014
He Mu, Subramanian Radhika, Bangs Fiona, Omelchenko Tatiana, Liem Karel F, Kapoor Tarun M, Anderson Kathryn V
Abstract excerpt
Mammalian Hedgehog (Hh) signal transduction requires a primary cilium, a microtubule-based organelle, and the Gli-Sufu complexes that mediate Hh signalling, which are enriched at cilia tips. Kif7, a kinesin-4 family protein, is a conserved regulator of the Hh signalling pathway and a human ciliopathy protein. Here we show that Kif7 localizes to the cilium tip, the site of microtubule plus ends, where it limits...
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