Article
Cilia-dependent GLI processing in neural crest cells is required for tongue development.
Developmental biology - 15 Apr 2017
Millington Grethel, Elliott Kelsey H, Chang Ya-Ting, Chang Ching-Fang, Dlugosz Andrzej, Brugmann Samantha A
Abstract excerpt
Ciliopathies are a class of diseases caused by the loss of a ubiquitous, microtubule-based organelle called a primary cilium. Ciliopathies commonly result in defective development of the craniofacial complex, causing midfacial defects, craniosynostosis, micrognathia and aglossia. Herein, we explored how the conditional loss of primary cilia on neural crest cells (Kif3af/f;Wnt1-Cre) generated aglossia. On a...
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