Article
The tumor suppressor gene fat modulates the EGFR-mediated proliferation control in the imaginal tissues of Drosophila melanogaster.
Mechanisms of development - 1 Feb 2005
Garoia Flavio, Grifoni Daniela, Trotta Vincenzo, Guerra Daniela, Pezzoli Maria Cristina, Cavicchi Sandro
Abstract excerpt
Molecules involved in cell adhesion can regulate both early signal transduction events, triggered by soluble factors, and downstream events involved in cell cycle progression. Correct integration of these signals allows appropriate cellular growth, differentiation and ultimately tissue morphogenesis, but incorrect interpretation contributes to pathologies such as tumor growth. The Fat cadherin is a tumor...
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