Article
Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila.
Genes & development - 15 Jun 1995
Clark H F, Brentrup D, Schneitz K, Bieber A, Goodman C, Noll M
Abstract excerpt
Mutations in the dachsous gene of Drosophila lead to striking defects in the morphogenesis of the thorax, legs, and wings. The dachsous gene has been cloned and shown to encode a huge transmembrane protein that is a member of the cadherin superfamily, similar to the fat gene reported previously. Both the Dachsous and Fat proteins contain large tandem arrays of cadherin domains--27 and 34, respectively--as...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Brain
- Cadherins
- DNA, Complementary
- Drosophila Proteins
- Drosophila melanogaster
- Ectoderm
- Embryo, Nonmammalian
