Article
Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.
Nature genetics - 1 Mar 2013
Morris Luc G T, Kaufman Andrew M, Gong Yongxing, Ramaswami Deepa, Walsh Logan A, Turcan Şevin, Eng Stephanie, Kannan Kasthuri, Zou Yilong, Peng Luke, Banuchi Victoria E, Paty Phillip, Zeng Zhaoshi, Vakiani Efsevia, Solit David, Singh Bhuvanesh, Ganly Ian, Liau Linda, Cloughesy Timothy C, Mischel Paul S, Mellinghoff Ingo K, Chan Timothy A
Abstract excerpt
Aberrant Wnt signaling can drive cancer development. In many cancer types, the genetic basis of Wnt pathway activation remains incompletely understood. Here, we report recurrent somatic mutations of the Drosophila melanogaster tumor suppressor-related gene FAT1 in glioblastoma (20.5%), colorectal cancer (7.7%), and head and neck cancer (6.7%). FAT1 encodes a cadherin-like protein, which we found is able to...
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