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Article

Function and cancer genomics of FAT family genes

17 Oct 2012

Abstract excerpt

FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT1 and FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by γ‑secretase to release intracellular domain (ICD). Ena/VAPS‑binding to FAT1 induces actin polymerization at lamellipodia and filopodia to promote cell migration, while...

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Identifiers

PMID: 23076869
DOI: 10.3892/ijo.2012.1669

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