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Article

Inter-Subject Variability in OCT1 Activity in 27 Batches of Cryopreserved Human Hepatocytes and Association with OCT1 mRNA Expression and Genotype.

Pharmaceutical research - 1 Jun 2017

Fattah Sarinj, Shinde Abhijit Babaji, Matic Maja, Baes Myriam, van Schaik Ron H N, Allegaert Karel, Parmentier Celine, Richert Lysiane, Augustijns Patrick, Annaert Pieter

Abstract excerpt

PURPOSE: OCT1/3 (Organic Cation Transporter-1 and -3; SLC22A1/3) are transmembrane proteins localized at the basolateral membrane of hepatocytes. They mediate the uptake of cationic endogenous compounds and/or xenobiotics. The present study was set up to verify whether the previously observed variability in OCT activity in hepatocytes may be explained by inter-individual differences in OCT1/3 mRNA levels or OCT1...

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PMID: 28364304
DOI: 10.1007/s11095-017-2148-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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