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Article

Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms.

Journal of cellular physiology - 1 Nov 2009

Hassan Ranya, Suzu Shinya, Hiyoshi Masateru, Takahashi-Makise Naoko, Ueno Takamasa, Agatsuma Tsutomu, Akari Hirofumi, Komano Jun, Takebe Yutaka, Motoyoshi Kazuo, Okada Seiji

Abstract excerpt

HIV-1 Nef accelerates the progression to AIDS by binding with and activating a Src kinase Hck, but underlying molecular basis is not understood. We revealed that Nef disturbed N-glycosylation/trafficking of a cytokine receptor Fms in an Hck-dependent manner, a possible trigger to worsen uncontrolled immune system. Here, we provide direct evidence that dys-regulated activation of Hck pre-localized to the Golgi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19585521
DOI: 10.1002/jcp.21878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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