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Article

HIV-1 Nef disrupts antigen presentation early in the secretory pathway.

The Journal of biological chemistry - 1 Apr 2005

Kasper Matthew R, Roeth Jeremiah F, Williams Maya, Filzen Tracey M, Fleis Rebekah I, Collins Kathleen L

Abstract excerpt

Human immunodeficiency virus, type 1 Nef disrupts viral antigen presentation and promotes viral immune evasion from cytotoxic T lymphocytes. There is evidence that Nef acts early in the secretory pathway to redirect major histocompatibility complex class I (MHC-I) from the trans-Golgi network to the endolysosomal pathway. However, a competing model suggests that Nef acts much later by accelerating MHC-I turnover...

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Share to Adenoviridae
Share to Antigen Presentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, nef

Share to Genes, MHC Class I

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Source

Identifiers

PMID: 15653685
DOI: 10.1074/jbc.M413538200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 Nef disrupts antigen presentation early in the secretory pathway.PMID 15653685Read ↗

HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tailSemantic proximity Read ↗

HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements.Semantic proximity Read ↗

HIV ‐1 Nef: Taking Control of Protein TraffickingSemantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Nef: Adapting to Intracellular Trafficking PathwaysSemantic proximity Read ↗

An MHC-I Cytoplasmic Domain/HIV-1 Nef Fusion Protein Binds Directly to the μ Subunit of the AP-1 Endosomal Coat ComplexSemantic proximity Read ↗

How HIV Nef Proteins Hijack Membrane Traffic To Promote InfectionSemantic proximity Read ↗

The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail.Semantic proximity Read ↗

Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation of Nef with HLA-A2.Semantic proximity Read ↗

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef proteinSemantic proximity Read ↗

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.Semantic proximity Read ↗

HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recyclingSemantic proximity Read ↗

Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity.Semantic proximity Read ↗

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