Article
An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.
Molecular biology of the cell - 1 Jun 2012
Dikeakos Jimmy D, Thomas Laurel, Kwon Grace, Elferich Johannes, Shinde Ujwal, Thomas Gary
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) accessory protein Nef directs virus escape from immune surveillance by subverting host cell intracellular signaling and membrane traffic to down-regulate cell-surface major histocompatibility complex class I (MHC-I). The interaction of Nef with the sorting proteins PACS-1 and PACS-2 mediates key signaling and trafficking steps required for Nef-mediated MHC-I...
Topics
- Amino Acid Sequence
- Amino Acids
- Binding Sites
- Down-Regulation
- Endosomes
- Furin
- HeLa Cells
- Histocompatibility Antigens Class I
- Humans
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Structure, Secondary