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HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling

14 Nov 2016

Abstract excerpt

A defining characteristic of HIV-1 infection is the ability of the virus to persist within the host. Specifically, MHC-I downregulation by the HIV-1 accessory protein Nef is of critical importance in preventing infected cells from cytotoxic T-cell mediated killing. Nef downregulates MHC-I by modulating the host membrane trafficking machinery, resulting in the endocytosis and eventual sequestration of MHC-I within...

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PMID: 27841315
DOI: 10.1038/srep37021

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