Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.

Journal of molecular biology - 16 Nov 2007

Trible Ronald P, Emert-Sedlak Lori, Wales Thomas E, Ayyavoo Velpandi, Engen John R, Smithgall Thomas E

Abstract excerpt

Activation of Src family kinases by human immunodeficiency virus type 1 (HIV-1) Nef may play an important role in the pathogenesis of HIV/AIDS. Here we investigated whether diverse Nef sequences universally activate Hck, a Src family member expressed in macrophages and other HIV-1 target cells. In general, we observed that Hck activation is a highly conserved Nef function. However, we identified an unusual Nef...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Deuterium Exchange Measurement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dimerization

Share to Green Fluorescent Proteins

Share to Immunoblotting

Share to Mass Spectrometry

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Transformation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 17920628
DOI: 10.1016/j.jmb.2007.09.009
PMCID: PMC2117379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.PMID 17920628Read ↗

Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase.Semantic proximity Read ↗

Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.Semantic proximity Read ↗

Dynamic Evolution of the Human Immunodeficiency Virus Type 1 Pathogenic Factor, NefSemantic proximity Read ↗

Synergy and allostery in ligand binding by HIV-1 NefSemantic proximity Read ↗

Functional characterization of HIV-1 Nef mutants in the context of viral infection.Semantic proximity Read ↗

Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.Semantic proximity Read ↗

Functional and structural defects in HIV type 1 nef genes derived from pediatric long-term survivors.Semantic proximity Read ↗

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1Semantic proximity Read ↗

Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms.Semantic proximity Read ↗

HIV-1 Nef activates proviral DNA transcription by recruiting Src kinase to phosphorylate host protein Nef-associated factor 1 to compromise its viral restrictive functionSemantic proximity Read ↗

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling.Semantic proximity Read ↗

Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.