Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent mutations in the 3'-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours.

European journal of human genetics : EJHG - 1 Oct 2008

Dierssen Jan Willem F, van Puijenbroek Marjo, Dezentjé David A, Fleuren Gert Jan, Cornelisse Cees J, van Wezel Tom, Offringa Rienk, Morreau Hans

Abstract excerpt

Microsatellite repeats are frequently found to be mutated in microsatellite-instable colorectal tumours. This suggests that these mutations are important events during tumour development. We have observed frequent mutations in microsatellite-instable (MSI-H) tumours and cell lines of a conserved A14 repeat within the 3'-untranslated region of the interferon-gamma receptor 1 gene (IFNGR1). The repeat was mutated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Interferon gamma Receptor

Share to Microsatellite Instability

Share to Microsatellite Repeats

Share to Mutation

Share to Receptors, Interferon

Source

Identifiers

PMID: 18414508
DOI: 10.1038/ejhg.2008.81

Genes

IFNGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent mutations in the 3'-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours.PMID 18414508Read ↗

An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.Semantic proximity Read ↗

Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers.Semantic proximity Read ↗

Background mutation frequency in microsatellite-unstable colorectal cancer.Semantic proximity Read ↗

Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers.Semantic proximity Read ↗

Mutational targets in colorectal cancer cells with microsatellite instability.Semantic proximity Read ↗

Screening for microsatellite instability identifies frequent 3'-untranslated region mutation of the RB1-inducible coiled-coil 1 gene in colon tumors.Semantic proximity Read ↗

The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers.Semantic proximity Read ↗

Conservation of mononucleotide repeats within 3' and 5' untranslated regions and their instability in MSI-H colorectal cancer.Semantic proximity Read ↗

Regional reproducibility of microsatellite instability in sporadic colorectal cancer.Semantic proximity Read ↗

Apparent protection from instability of repeat sequences in cancer-related genes in replication error positive gastrointestinal cancers.Semantic proximity Read ↗

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.Semantic proximity Read ↗

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.