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Article

An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors.

Cancer research - 15 Dec 2004

Amador Maria L, Oppenheimer Darin, Perea Sofia, Maitra Anirban, Cusatis George, Cusati George, Iacobuzio-Donahue Christi, Baker Sharyn D, Ashfaq Raheela, Takimoto Chris, Forastiere Arlene, Hidalgo Manuel

Abstract excerpt

This study tested the hypothesis that the number of CA single sequence repeat (CA-SSR) in the intron 1 of the epidermal growth factor receptor (egfr) gene, which affects transcription efficiency of the gene, is associated with the response to EGFR inhibitors. To this end, we determined the number of CA dinucleotides in the intron 1 of the egfr gene in a panel of 12 head and neck cancer cell lines that lack egfr...

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Source

Identifiers

PMID: 15604284
DOI: 10.1158/0008-5472.CAN-04-1036

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors.PMID 15604284Read ↗

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