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Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer

23 Mar 2022

Abstract excerpt

Abstract Altered RNA expression of repetitive sequences and retrotransposition are frequently seen in colorectal cancer, implicating a functional importance of repeat activity in cancer progression. We show the nucleoside reverse transcriptase inhibitor 3TC targets activities of these repeat elements in colorectal cancer preclinical models with a preferential effect in p53-mutant cell lines linked with direct...

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PMID: 35320348
DOI: 10.1158/2159-8290.cd-21-1117

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