Article
Intron 1 CA dinucleotide repeat polymorphism and mutations of epidermal growth factor receptor and gefitinib responsiveness in non-small-cell lung cancer.
Pharmacogenetics and genomics - 1 May 2007
Han Sae-Won, Jeon Yoon Kyung, Lee Kyung-Hun, Keam Bhumsuk, Hwang Pil Gyu, Oh Do-Youn, Lee Se-Hoon, Kim Dong-Wan, Im Seock-Ah, Chung Doo Hyun, Heo Dae Seog, Bang Yung-Jue, Kim Tae-You
Abstract excerpt
OBJECTIVE: Limited availability of tumoral tissue in non-small-cell lung cancer and presence of epidermal growth factor receptor mutation-independent responses call for investigation of other molecular predictive marker of gefitinib responsiveness. Therefore, CA repeat polymorphism in intron 1 was analyzed for its association with gefitinib responsiveness together with epidermal growth factor receptor mutation in...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
- Carcinoma, Non-Small-Cell Lung
- Dinucleotide Repeats
- Disease-Free Survival
- ErbB Receptors
- Female
- Gefitinib
- Humans
- Introns
- Lung Neoplasms