Article
Frequent alterations in gene expression in colon tumor cells of the microsatellite mutator phenotype.
Mutation research - 21 Mar 1997
Ricote M, Geller P, Perucho M
Abstract excerpt
Tumors of the microsatellite mutator phenotype (MMP) are characterized by the accumulation of many thousands of somatic mutations in tracts of simple repeated sequences or microsatellites. Using arbitrarily primed PCR fingerprinting of RNA (RAP-PCR), we have comparatively analyzed the overall gen...
Topics
- Blotting, Northern
- Blotting, Southern
- Clone Cells
- Cloning, Molecular
- Colorectal Neoplasms
- DNA Primers
- Gene Expression Regulation, Neoplastic
- Humans
- Hybrid Cells
- Microsatellite Repeats
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- RNA
- Tumor Cells, Cultured