Article
Frequent alterations in gene expression in colon tumor cells of the microsatellite mutator phenotype.
Mutation research - 21 Mar 1997
Ricote M, Geller P, Perucho M
Abstract excerpt
Tumors of the microsatellite mutator phenotype (MMP) are characterized by the accumulation of many thousands of somatic mutations in tracts of simple repeated sequences or microsatellites. Using arbitrarily primed PCR fingerprinting of RNA (RAP-PCR), we have comparatively analyzed the overall gene expression patterns of several colorectal tumor cell lines with and without the MMP. A reproducible pattern of 30-40...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
