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Article

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

Proceedings of the National Academy of Sciences of the United States of America - 19 Oct 2004

Fenske Timothy S, Pengue Gina, Mathews Vikram, Hanson Piia T, Hamm Sarah E, Riaz Noor, Graubert Timothy A

Abstract excerpt

The t(8;21)(q22;q22) translocation, present in 10-15% of acute myeloid leukemia (AML) cases, generates the AML1/ETO fusion protein. To study the role of AML1/ETO in the pathogenesis of AML, we used the Ly6A locus that encodes the well characterized hematopoietic stem cell marker, Sca1, to target expression of AML1/ETO to the hematopoietic stem cell compartment in mice. Whereas germ-line expression of AML1/ETO...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15477599
DOI: 10.1073/pnas.0400751101
PMCID: PMC524043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.PMID 15477599Read ↗

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