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Article

Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model.

Blood - 25 Nov 2010

Sinenko Sergey A, Hung Tony, Moroz Tatiana, Tran Quynh-Minh, Sidhu Sohrab, Cheney Matthew D, Speck Nancy A, Banerjee Utpal

Abstract excerpt

Among mutations in human Runx1/AML1 transcription factors, the t(8;21)(q22;q22) genomic translocation that creates an AML1-ETO fusion protein is implicated in etiology of the acute myeloid leukemia. To identify genes and components associated with this oncogene we used Drosophila as a genetic model. Expression of AML1-ETO caused an expansion of hematopoietic precursors in Drosophila, which expressed high levels...

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Source

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Identifiers

PMID: 20688956
DOI: 10.1182/blood-2010-03-276998
PMCID: PMC2996118

Genes

SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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