Article
Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.
Molecular and cellular biology - 1 Sept 2009
Liu Ying, Warfield Linda, Zhang Chao, Luo Jie, Allen Jasmina, Lang Walter H, Ranish Jeffrey, Shokat Kevan M, Hahn Steven
Abstract excerpt
The Saccharomyces cerevisiae kinase Bur1 is involved in coupling transcription elongation to chromatin modification, but not all important Bur1 targets in the elongation complex are known. Using a chemical genetics strategy wherein Bur1 kinase was engineered to be regulated by a specific inhibitor, we found that Bur1 phosphorylates the Spt5 C-terminal repeat domain (CTD) both in vivo and in isolated elongation...
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