Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis.

The Journal of biological chemistry - 31 Oct 2003

Pei Yi, Shuman Stewart

Abstract excerpt

Schizosaccharomyces pombe Cdk9/Pch1 protein kinase is a functional ortholog of the essential Saccharomyces cerevisiae Bur1/Bur2 kinase and a putative ortholog of metazoan P-TEFb (Cdk9/cyclin T). SpCdk9/Pch1 phosphorylates of the carboxyl-terminal domain (CTD) of the S. pombe transcription elongat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Cations
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclins

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Serine

Share to Transcriptional Elongation Factors

Source

Identifiers

PMID: 12904290
DOI: 10.1074/jbc.M307319200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12904290-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis.PMID 12904290Read ↗

Characterization of the Schizosaccharomyces pombe Spt5-Spt4 complex.Semantic proximity Read ↗

Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control.Semantic proximity Read ↗

Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTD.Semantic proximity Read ↗

Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast.Semantic proximity Read ↗

Pch1(+), a second essential C-type cyclin gene in Schizosaccharomyces pombe.Semantic proximity Read ↗

Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo.Semantic proximity Read ↗

A Cdk9-PP1 kinase-phosphatase switch regulates the elongation-termination transition of RNA polymerase IISemantic proximity Read ↗

The length, phosphorylation state, and primary structure of the RNA polymerase II carboxyl-terminal domain dictate interactions with mRNA capping enzymes.Semantic proximity Read ↗

Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1.Semantic proximity Read ↗

A cancer-derived mutation in the PSTAIRE helix of cyclin-dependent kinase 2 alters the stability of cyclin binding.Semantic proximity Read ↗

The two faces of Cdk8, a positive/negative regulator of transcription.Semantic proximity Read ↗

A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.