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Article

Regulation of histone modification and cryptic transcription by the Bur1 and Paf1 complexes.

The EMBO journal - 14 Nov 2007

Chu Yaya, Simic Rajna, Warner Marcie H, Arndt Karen M, Prelich Gregory

Abstract excerpt

The Bur1-Bur2 and Paf1 complexes function during transcription elongation and affect histone modifications. Here we describe new roles for Bur1-Bur2 and the Paf1 complex. We find that histone H3 K36 tri-methylation requires specific components of the Paf1 complex and that K36 tri-methylation is more strongly affected at the 5' ends of genes in paf1delta and bur2delta strains in parallel with increased acetylation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17948059
DOI: 10.1038/sj.emboj.7601887
PMCID: PMC2080810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of histone modification and cryptic transcription by the Bur1 and Paf1 complexes.PMID 17948059Read ↗

A nucleosome surface formed by histone H4, H2A, and H3 residues is needed for proper histone H3 Lys36 methylation, histone acetylation, and repression of cryptic transcription.Semantic proximity Read ↗

The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2.Semantic proximity Read ↗

Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.Semantic proximity Read ↗

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The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.Semantic proximity Read ↗

NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3.Semantic proximity Read ↗

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.Semantic proximity Read ↗

NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5.Semantic proximity Read ↗

Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains.Semantic proximity Read ↗

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