Article
The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2.
Molecular and cellular biology - 1 Apr 2006
Chu Yaya, Sutton Ann, Sternglanz Rolf, Prelich Gregory
Abstract excerpt
BUR1 and BUR2 encode the catalytic and regulatory subunits of a cyclin-dependent protein kinase complex that is essential for normal growth and has a general role in transcription elongation. To gain insight into its specific role in vivo, we identified mutations that reverse the severe growth defect of bur1Delta cells. This selection identified mutations in SET2, which encodes a histone methylase that targets...
Topics
- Alleles
- Blotting, Western
- Chromatin Immunoprecipitation
- Cyclin-Dependent Kinases
- DNA-Binding Proteins
- Fungal Proteins
- Gene Deletion
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Histone-Lysine N-Methyltransferase