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Article

Bur1 kinase is required for efficient transcription elongation by RNA polymerase II.

Molecular and cellular biology - 1 Oct 2003

Keogh Michael-Christopher, Podolny Vladimir, Buratowski Stephen

Abstract excerpt

The Saccharomyces cerevisiae cyclin-dependent kinase (CDK) Bur1 (Sgv1) may be homologous to mammalian Cdk9, which functions in transcriptional elongation. Although Bur1 can phosphorylate the Rpb1 carboxy-terminal domain (CTD) kinase in vitro, it has no strong specificity within the consensus heptapeptide YSPTSPS for Ser2 or Ser5. BUR1 mutants are sensitive to the drugs 6-azauracil and mycophenolic acid and...

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Identifiers

PMID: 12972617
DOI: 10.1128/MCB.23.19.7005-7018.2003
PMCID: PMC193923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bur1 kinase is required for efficient transcription elongation by RNA polymerase II.PMID 12972617Read ↗

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