Article
A function of yeast mRNA cap methyltransferase, Abd1, in transcription by RNA polymerase II.
Molecular cell - 13 Feb 2004
Schroeder Stephanie C, Zorio Diego A R, Schwer Beate, Shuman Stewart, Bentley David
Abstract excerpt
Capping enzymes bind the phosphorylated pol II CTD permitting cotranscriptional capping of nascent pre-mRNAs. We asked whether these interactions influence pol II function using ChIP in ts mutants of yeast capping enzymes. Pol II occupancy at the 5' ends of PGK1, ENO2, GAL1, and GAL10 was reduced by inactivation of the methyltransferase, Abd1, but not the guanylyltransferase, Ceg1, suggesting that Abd1...
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