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Article

Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex.

The EMBO journal - 19 Aug 2009

Janssen Bert J C, Gomes Lucio, Koning Roman I, Svergun Dmitri I, Koster Abraham J, Fritzinger David C, Vogel Carl-Wilhelm, Gros Piet

Abstract excerpt

Immune protection by the complement system critically depends on assembly of C3 convertases on the surface of pathogens and altered host cells. These short-lived protease complexes are formed through pro-convertases, which for the alternative pathway consist of the complement component C3b and the pro-enzyme factor B (FB). Here, we present the crystal structure at 2.2-A resolution, small-angle X-ray scattering...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19574954
DOI: 10.1038/emboj.2009.184
PMCID: PMC2735180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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