Article
Structure of complement component C2A: implications for convertase formation and substrate binding.
Structure (London, England : 1993) - 1 Oct 2006
Milder Fin J, Raaijmakers Hans C A, Vandeputte Mitja D A A, Schouten Arie, Huizinga Eric G, Romijn Roland A, Hemrika Wieger, Roos Anja, Daha Mohamed R, Gros Piet
Abstract excerpt
C2a provides the catalytic center to the convertase complexes of the classical and lectin-binding pathways of complement activation. We determined two crystal structures of full-length C2a, with and without a pseudo ligand bound. Both structures reveal a near-active conformation of the catalytic center of the serine protease domains, while the von Willebrand factor A-type domains display an intermediate...
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