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Article

Structural biology of C1: dissection of a complex molecular machinery

1 Apr 2001

Abstract excerpt

Summary: The classical pathway of complement is initiated by the C1 complex, a multimolecular protease comprising a recognition subunit (C1q) and two modular serine proteases (C1r and C1s) associated as a Ca 2+ ‐dependent tetramer (C1s‐C1r‐C1r‐C1s). Early studies have allowed identification of specialized functional domains in these proteins and have led to low‐resolution models of the C1 complex. The objective...

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Identifiers

PMID: 11414355
DOI: 10.1034/j.1600-065x.2001.1800112.x

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