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Article

Structural insight into proteolytic activation and regulation of the complement system.

Immunological reviews - 1 Nov 2016

Schatz-Jakobsen Janus A, Pedersen Dennis V, Andersen Gregers R

Abstract excerpt

The complement system is a highly complex and carefully regulated proteolytic cascade activated through three different pathways depending on the activator recognized. The structural knowledge regarding the intricate proteolytic enzymes that activate and control complement has increased dramatically over the last decade. This development has been pivotal for understanding how mutations within complement proteins...

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Identifiers

PMID: 27782336
DOI: 10.1111/imr.12465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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