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Structural and functional studies of complement inhibitor C4b-binding protein

1 Nov 2002

Abstract excerpt

C4b-binding protein (C4BP) is a potent inhibitor of the classical pathway of the complement system. This large plasma glycoprotein consists of seven identical alpha-chains and a unique beta-chain held together by disulphide bridges. Both types of subunits are composed almost exclusively of complement control protein domains (CCPs). Using homology-based computer modelling and mutagenesis of recombinant proteins we...

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PMID: 12440957
DOI: 10.1042/bst0300978

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