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Article

Structural biology of the alternative pathway convertase

1 Apr 2001

Abstract excerpt

Complement convertases are bimolecular complexes expressing protease activity only against C3 and C5. Their action is necessary for production of the biological activities of the complement system. Formation of these complexes proceeds through sequential protein-protein interactions and proteolytic cleavages of high specificity. Recent structural, mutational and functional data on factors D and B have...

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Identifiers

PMID: 11414354
DOI: 10.1034/j.1600-065x.2001.1800111.x

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