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Article

Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement

25 Apr 2015

Abstract excerpt

Complement component C4 is a central protein in the classical and lectin pathways within the complement system. During activation of complement, its major fragment C4b becomes covalently attached to the surface of pathogens and altered self-tissue, where it acts as an opsonin marking the surface for removal. Moreover, C4b provides a platform for assembly of the proteolytically active convertases that mediate...

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PMID: 25911760
DOI: 10.4049/jimmunol.1500087

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