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Article

Structure of C3b in complex with CRIg gives insights into regulation of complement activation.

Nature - 9 Nov 2006

Wiesmann Christian, Katschke Kenneth J, Yin JianPing, Helmy Karim Y, Steffek Micah, Fairbrother Wayne J, McCallum Scott A, Embuscado Lizette, DeForge Laura, Hass Philip E, van Lookeren Campagne Menno

Abstract excerpt

The complement system is a key part of the innate immune system, and is required for clearance of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Crystallography, X-Ray

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Source

Identifiers

PMID: 17051150
DOI: 10.1038/nature05263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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