Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines

26 Jan 2018

Abstract excerpt

Genetically predisposed CTLA4 insufficiency in humans is associated with gastric cancer development, which is paradoxical to the prototypical role of CTLA4 in suppressing antitumor immunity. CTLA4 is a critical immune checkpoint against autoimmune disorders. Autoimmunity has been implicated in protumor or antitumor activities. Here, we show that CTLA4 insufficiency initiates de novo tumorigenesis in the mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Diabetes and associated disorders
Share to Immunodeficiency and Autoimmune Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29374027
DOI: 10.1084/jem.20171971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokinesPMID 29374027Read ↗

A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor developmentSemantic proximity Read ↗

A critical role of epithelial MHCII in initiation of autoimmune tumorigenesis and sustaining premalignancy growth in the stomachSemantic proximity Read ↗

Autoimmunity and <i>H. pylori</i> infection cooperatively promote epithelial tumorigenic differentiation and systemic immune modulationSemantic proximity Read ↗

Inhibition of the tuft cell/ILC2 axis reduces gastric tumor development in miceSemantic proximity Read ↗

Inflammation and Cancer: A Temporal Perspective on Emerging Cellular and Molecular Mechanisms, Focusing on Gastrointestinal CancersSemantic proximity Read ↗

Dynamic changes of the immune microenvironment in the development of gastric cancer caused by inflammationSemantic proximity Read ↗

Dual Roles for Immunity in Gastrointestinal CancersSemantic proximity Read ↗

Circulating inflammatory ILC2s as a biomarker of gastric cancer progressionSemantic proximity Read ↗

Microbiota-dependent expression of CTLA-4 by innate lymphoid cells restrains IFNγ dependent colitisSemantic proximity Read ↗

Inflaming gastrointestinal oncogenic programming.Semantic proximity Read ↗

Innate lymphoid cells involve in tumorigenesis.Semantic proximity Read ↗

The Immune Underpinnings of Barrett’s-Associated Adenocarcinogenesis: a Retrial of Nefarious Immunologic Co-ConspiratorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.