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CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in <i>ApcMin/+</i> Mice

15 May 2005

Abstract excerpt

Colorectal cancer in humans results from sequential genetic changes in intestinal epithelia commencing with inactivation of the APC tumor suppressor gene. Roles for host immunity in epithelial tumorigenesis are poorly understood. It has been previously shown that CD4+CD25+ lymphocytes inhibit colitis-associated epithelial tumors in Rag-deficient mice. Here we show that addition of CD4+CD25+ lymphocytes in...

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PMID: 15899788
DOI: 10.1158/0008-5472.can-04-3104

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