Article
Genetic and epigenetic regulation of YKL-40 in childhood.
The Journal of allergy and clinical immunology - 1 Mar 2018
Guerra Stefano, Melén Erik, Sunyer Jordi, Xu Cheng-Jian, Lavi Iris, Benet Marta, Bustamante Mariona, Carsin Anne-Elie, Dobaño Carlota, Guxens Mònica, Tischer Christina, Vrijheid Martine, Kull Inger, Bergström Anna, Kumar Ashish, Söderhäll Cilla, Gehring Ulrike, Dijkstra Dorieke J, van der Vlies Pieter, Wickman Magnus, Bousquet Jean, Postma Dirkje S, Anto Josep M, Koppelman Gerard H
Abstract excerpt
BACKGROUND: Circulating levels of the chitinase-like protein YKL-40 are influenced by genetic variation in its encoding gene (chitinase 3-like 1 [CHI3L1]) and are increased in patients with several diseases, including asthma. Epigenetic regulation of circulating YKL-40 early in life is unknown. OBJECTIVE: We sought to determine (1) whether methylation levels at CHI3L1 CpG sites mediate the association of CHI3L1...
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