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Article

Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus.

The Journal of rheumatology - 1 Aug 2009

Hellquist Anna, Järvinen Tiina M, Koskenmies Sari, Zucchelli Marco, Orsmark-Pietras Christina, Berglind Linda, Panelius Jaana, Hasan Taina, Julkunen Heikki, D'Amato Mauro, Saarialho-Kere Ulpu, Kere Juha

Abstract excerpt

OBJECTIVE: Several candidate genes have been implicated in susceptibility for systemic lupus erythematosus (SLE), a complex autoimmune disease. The proposed genes include members of the type I interferon (IFN) pathway and genes involved in immunological defense functions. Our aim was to systematically replicate 6 such genes, TYK2, IRF5, CTLA4, PDCD1, FCGR2A, and NOD2. METHODS: Single-nucleotide polymorphisms in...

Read the complete abstract on PubMed

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Share to Apoptosis Regulatory Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon Regulatory Factors

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Source

Identifiers

PMID: 19567624
DOI: 10.3899/jrheum.081160

Genes

TYK2
CTLA4
NOD2
PDCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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