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Article

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.

European journal of human genetics : EJHG - 1 Apr 2011

Sandling Johanna K, Garnier Sophie, Sigurdsson Snaevar, Wang Chuan, Nordmark Gunnel, Gunnarsson Iva, Svenungsson Elisabet, Padyukov Leonid, Sturfelt Gunnar, Jönsen Andreas, Bengtsson Anders A, Truedsson Lennart, Eriksson Catharina, Rantapää-Dahlqvist Solbritt, Mälarstig Anders, Strawbridge Rona J, Hamsten Anders, Criswell Lindsey A, Graham Robert R, Behrens Timothy W, Eloranta Maija-Leena, Alm Gunnar, Rönnblom Lars, Syvänen Ann-Christine

Abstract excerpt

Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease in which the type I interferon pathway has a crucial role. We have previously shown that three genes in this pathway, IRF5, TYK2 and STAT4, are strongly associated with risk for SLE. Here, we investigated 78 genes involved in the type I interferon pathway to identify additional SLE susceptibility loci. First, we genotyped 896 single-nucleotide...

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Source

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Identifiers

PMID: 21179067
DOI: 10.1038/ejhg.2010.197
PMCID: PMC3060320

Genes

IKBKE
STAT1
STAT4
TANK
TRAF6
TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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