Article
Allelic loss at TP53 in metastatic human endometrial carcinomas.
Clinical & experimental metastasis - 1 Jan 2009
Szewczuk Wiktor, Skomra Danuta, Cybulski Marek, Przadka-Rabaniuk Dorota, Filip Agata, Jóźwik Maciej, Olcha Piotr, Roessner Albert, Semczuk Andrzej
Abstract excerpt
Loss of heterozygosity (LOH) is implicated in the initiation and progression of various human neoplasia, and is observed in both early or in advanced-stage human cancers. The current study was aimed at investigating the frequency of LOH TP53 in human endometrial carcinoma (EC) metastases. LOH was analyzed using 3 intragenic polymorphisms in 38 primary ECs and corresponding metastatic lesions. Allelic loss at...
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