Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and biological characteristics associated with loss-of-heterozygosity in endometrial cancer.

Journal of gynecologic oncology - 1 Jan 2026

Blanc-Durand Felix, Rouleau Etienne, Pautier Patricia, Ngoi Natalie, Lim Yi Wan, Lim Siew Eng, Leary Alexandra, Tan David Sp

Abstract excerpt

OBJECTIVE: Genomic instability has been identified in a subgroup of endometrial cancers (ECs) that are predominantly TP53 mutated (TP53mut). We report the features associated with loss-of-heterozygosity (LOH) in EC. METHODS: We conducted a retrospective analysis of EC patients from France and Singapore. All patients underwent comprehensive molecular profiling using the tumor based FoundationOne CDX panel. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Endometrioid
Share to Endometrial Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to France

Share to Loss of Heterozygosity

Share to Microsatellite Instability

Share to Receptors, Estrogen

Share to Receptors, Progesterone

Share to Singapore

Source

Open in PubMed Open full text

Identifiers

PMID: 40707423
DOI: 10.3802/jgo.2026.37.e10
PMCID: PMC12867668

Genes

TP53
ARID1A
BRCA1
CTNNB1
PIK3CA
POLE
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and biological characteristics associated with loss-of-heterozygosity in endometrial cancer.PMID 40707423Read ↗

Molecular analysis of endometrial serous carcinoma reveals distinct clinicopathologic and genomic subgroups.Semantic proximity Read ↗

Mutation and allelic loss of the p53 gene in endometrial carcinoma. Incidence and outcome in 92 surgical patients.Semantic proximity Read ↗

Correlative Assessment of p53 Immunostaining Patterns and TP53 Mutation Status by Next-Generation Sequencing in High-Grade Endometrial Carcinomas.Semantic proximity Read ↗

Clinical Profile and Survival Outcome of Endometrial Cancer with p53 MutationSemantic proximity Read ↗

Germline BRCA -Associated Endometrial Carcinoma Is a Distinct Clinicopathologic EntitySemantic proximity Read ↗

Clinicopathologic and Genomic Analysis of TP53-Mutated Endometrial Carcinomas.Semantic proximity Read ↗

Molecular Evaluation of Low-grade Low-stage Endometrial Cancer With and Without Recurrence.Semantic proximity Read ↗

Allelic loss at TP53 in metastatic human endometrial carcinomas.Semantic proximity Read ↗

Impact of TP53 somatic mutations on prognosis in endometrial cancer: a systematic review and meta-analysis.Semantic proximity Read ↗

Abnormal p53 expression is associated with poor outcomes in grade I or II, stage I, endometrioid carcinoma: a retrospective single-institute study.Semantic proximity Read ↗

Frequent Homologous Recombination Deficiency in High-grade Endometrial CarcinomasSemantic proximity Read ↗

Microsatellite instability, loss of heterozygosity, and loss of hMLH1 and hMSH2 protein expression in endometrial carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.