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Article

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2009

Imamachi Noritaka, Park Goon Ho, Lee Hyosang, Anderson David J, Simon Melvin I, Basbaum Allan I, Han Sang-Kyou

Abstract excerpt

The mechanisms that generate itch are poorly understood at both the molecular and cellular levels despite its clinical importance. To explore the peripheral neuronal mechanisms underlying itch, we assessed the behavioral responses (scratching) produced by s.c. injection of various pruritogens in PLCbeta3- or TRPV1-deficient mice. We provide evidence that at least 3 different molecular pathways contribute to the...

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Source

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Identifiers

PMID: 19564617
DOI: 10.1073/pnas.0905605106
PMCID: PMC2708751

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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