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iPSC-derived human sensory neurons reveal a subset of TRPV1 antagonists as anti-pruritic compounds

27 Dec 2024

Abstract excerpt

Signaling interplay between the histamine 1 receptor (H1R) and transient receptor potential cation channel subfamily V member 1 (TRPV1) in mediating histaminergic itch has been well-established in mammalian models, but whether this is conserved in humans remains to be confirmed due to the difficulties in obtaining human sensory neurons (SNs) for experimentation. Additionally, previously reported species-specific...

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PMID: 39732807
DOI: 10.1038/s41598-024-82549-7

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