Article

Direct sensitizing and activating effects of interleukin 31 are restricted to a single, functionally and transcriptionally classified porcine DRG neuron subtype

2026-04-14

Abstract excerpt

Interleukin-31 (IL-31) drives chronic pruritus in patients with dermatological and even certain systemic diseases. However, fast-onset anti-pruritic effects of blocking IL-31 receptors, for instance with nemolizumab in atopic dermatitis patients, are incompletely understood, in part due to ethical restrictions in humans and species differences to mice. Therefore, we used sensory neuron cultures from pig to investi...

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Literature Corpus work: 8b0c2952-d118-560b-9c42-ee0db97f9f70
DOI: 10.64898/2026.04.10.717660

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