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Article

PIEZO1 transduces mechanical itch in mice.

Nature - 1 Jul 2022

Hill Rose Z, Loud Meaghan C, Dubin Adrienne E, Peet Brooke, Patapoutian Ardem

Abstract excerpt

Itch triggers scratching, a behavioural defence mechanism that aids in the removal of harmful irritants and parasites1. Chemical itch is triggered by many endogenous and exogenous cues, such as pro-inflammatory histamine, which is released during an allergic reaction1. Mechanical itch can be triggered by light sensations such as wool fibres or a crawling insect2. In contrast to chemical itch pathways, which have...

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Identifiers

PMID: 35732741
DOI: 10.1038/s41586-022-04860-5
PMCID: PMC9259491

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PIEZO1 transduces mechanical itch in mice.PMID 35732741Read ↗

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A Piez-o the jigsaw: the Piezo1 channel in skin biologySemantic proximity Read ↗

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical ItchSemantic proximity Read ↗

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Targeting <i>Tmem63b</i> and <i>Piezo2</i> in C-fiber low threshold mechanoreceptor: limitation of <i>Vglut3</i> -IRES- <i>Cre</i>Semantic proximity Read ↗

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