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Article

A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord.

Nature - 9 Aug 2007

Sun Yan-Gang, Chen Zhou-Feng

Abstract excerpt

Itching, or pruritus, is defined as an unpleasant cutaneous sensation that serves as a physiological self-protective mechanism to prevent the body from being hurt by harmful external agents. Chronic itch represents a significant clinical problem resulting from renal diseases and liver diseases, as well as several serious skin diseases such as atopic dermatitis. The identity of the itch-specific mediator in the...

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Identifiers

PMID: 17653196
DOI: 10.1038/nature06029

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GRPR

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord.PMID 17653196Read ↗

Presynaptic inhibition of cutaneous afferents prevents self-generated itchSemantic proximity Read ↗

Mas-Related G Protein–Coupled Receptors and the Biology of Itch SensationSemantic proximity Read ↗

Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouseSemantic proximity Read ↗

A central role for R7bp in the regulation of itch sensation.Semantic proximity Read ↗

VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.Semantic proximity Read ↗

Molecular signature of pruriceptive MrgprA3 <sup>+</sup> neuronsSemantic proximity Read ↗

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.Semantic proximity Read ↗

Molecular recognition of itch-associated neuropeptides by bombesin receptorsSemantic proximity Read ↗

An Intra-brainstem Circuit for Pain-induced Inhibition of ItchSemantic proximity Read ↗

GPR15L is an epithelial inflammation-derived pruritogenSemantic proximity Read ↗

The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch.Semantic proximity Read ↗

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical ItchSemantic proximity Read ↗

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