Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness

Abstract excerpt

Significance Dermatitis is a major inflammatory skin condition that is associated with pruritus and affects millions of people worldwide. However, there is still little knowledge about the contribution of the cutaneous sensory neurons to the chronic disease. Here we show that chronic, but not acute, exposure to allergens/pruritogens induces robust itch in the dermatitis-prone Grhl3 PAR2/+ transgenic mouse line,...

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