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Article

The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch.

The Journal of investigative dermatology - 1 Nov 2018

Gao Tianle, Ma Haisha, Xu Bo, Bergman Jessica, Larhammar Dan, Lagerström Malin Charlotta

Abstract excerpt

Itch is a somatosensory modality that serves to alert an organism to harmful elements removable by scratching, such as parasites and chemical irritants. Recently, ablation or silencing of neuropeptide Y (NPY)-expressing spinal interneurons was reported to selectively enhance mechanical itch, whereas chemical itch was unaffected. We examined the effect of activating the NPY/Y1 receptor system on scratch behavior...

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Source

Identifiers

PMID: 29803641
DOI: 10.1016/j.jid.2018.05.008

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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