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Article

Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1.

Genetics - 1 Mar 2016

Schuster-Gossler Karin, Cordes Ralf, Müller Julia, Geffers Insa, Delany-Heiken Patricia, Taft Manuel, Preller Matthias, Gossler Achim

Abstract excerpt

The highly conserved Notch-signaling pathway mediates cell-to-cell communication and is pivotal for multiple developmental processes and tissue homeostasis in adult organisms. Notch receptors and their ligands are transmembrane proteins with multiple epidermal-growth-factor-like (EGF) repeats in their extracellular domains. In vitro the EGF repeats of mammalian ligands that are essential for Notch activation have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26801181
DOI: 10.1534/genetics.115.184515
PMCID: PMC4788113

Genes

DLL1
EGF
NOTCH1
NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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