Article
Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration.
Development (Cambridge, England) - 1 Sept 2013
Andersen Ditte Caroline, Laborda Jorge, Baladron Victoriano, Kassem Moustapha, Sheikh Søren Paludan, Jensen Charlotte Harken
Abstract excerpt
Muscle development and regeneration is tightly orchestrated by a specific set of myogenic transcription factors. However, factors that regulate these essential myogenic inducers remain poorly described. Here, we show that delta-like 1 homolog (Dlk1), an imprinted gene best known for its ability to inhibit adipogenesis, is a crucial regulator of the myogenic program in skeletal muscle. Dlk1(-/-) mice were...
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