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Article

The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila.

BMC developmental biology - 31 Jan 2008

Bray Sarah J, Takada Shuji, Harrison Emma, Shen Shing-Chuan, Ferguson-Smith Anne C

Abstract excerpt

BACKGROUND: Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function. RESULTS: Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular...

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Source

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Identifiers

PMID: 18237417
DOI: 10.1186/1471-213X-8-11
PMCID: PMC2268666

Genes

DLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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